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Original Article
- Age-stratified association between isolated diastolic hypertension and carotid intima-media thickness: results from the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) Study
- Minsung Cho, Jiyen Han, Hansol Choi, Jee-Seon Shim, Sun Jae Jung, Hokyou Lee, Hyeon Chang Kim
- Cardiovasc Prev Pharmacother. 2025;7(4):109-119. Published online October 24, 2025
- DOI: https://doi.org/10.36011/cpp.2025.7.e18
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Abstract
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Supplementary Material - Background
The clinical significance of isolated diastolic hypertension (IDH), particularly in relation to subclinical vascular changes, remains unclear and may vary across age groups. This study evaluated the age-stratified association between IDH and carotid intima-media thickness (IMT).
Methods
This cross-sectional study included 6,759 Korean adults aged 30–64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort. Participants with a history of cardiovascular disease or use of antihypertensive medication were excluded. Blood pressure was classified according to the 2017 American College of Cardiology/American Heart Association guidelines into four categories: no hypertension, IDH, isolated systolic hypertension, and systolic diastolic hypertension. Carotid IMT was measured by B-mode ultrasonography, and vascular thickening was defined as IMT ≥0.857 mm (75th percentile). Multivariable logistic regression analyses were performed with age stratification.
Results
Among participants younger than 50 years, IDH was significantly associated with carotid IMT thickening after adjustment for age, sex, body mass index, educational attainment, physical activity, smoking, diabetes, total cholesterol, high-density lipoprotein cholesterol, lipid-lowering drug use, C-reactive protein, and study site (odds ratio [OR], 1.57; 95% confidence interval [CI], 1.10–2.26). No significant association was observed in participants aged 50 years or older (OR, 0.89; 95% CI, 0.72–1.09). Both isolated systolic hypertension and systolic diastolic hypertension were associated with carotid IMT thickening in all age groups.
Conclusions
IDH was associated with subclinical vascular changes in younger adults but not in older adults. These findings highlight the age-specific nature of the association of IDH with cardiovascular risk.
Review Articles
- Stroke mechanisms and prevention in intracranial atherosclerosis
- Sang Hee Ha, Bum Joon Kim
- Cardiovasc Prev Pharmacother. 2025;7(3):94-101. Published online July 22, 2025
- DOI: https://doi.org/10.36011/cpp.2025.7.e10
- 7,192 View
- 66 Download
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Abstract
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- Intracranial atherosclerosis (ICAS) is a leading cause of ischemic stroke worldwide, with a particularly high prevalence among Asian populations. While early research primarily attributed this to systemic risk factors such as metabolic syndrome, more recent studies highlighted the importance of local factors, including vascular geometry and hemodynamic stress. The pathophysiology of ICAS-related stroke is multifactorial and encompasses in situ thrombotic occlusion, artery-to-artery embolism, hemodynamic compromise, and perforator branch occlusion. A thorough understanding of these mechanisms is essential for precise risk stratification and the development of targeted preventive strategies. Despite advancements in imaging techniques and pharmacological therapies, ICAS continues to present significant clinical challenges. This review synthesizes current knowledge on stroke mechanisms associated with ICAS and discusses emerging evidence for both primary and secondary prevention, including antithrombotic strategies, risk factor modification, and novel imaging approaches such as high-resolution vessel wall magnetic resonance imaging.
- Anti-inflammatory effects of colchicine on coronary artery disease
- Hun-Jun Park
- Cardiovasc Prev Pharmacother. 2022;4(1):7-12. Published online January 20, 2022
- DOI: https://doi.org/10.36011/cpp.2022.4.e5
- 15,382 View
- 192 Download
- 3 Citations
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Abstract
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- Inflammation plays a crucial role in the pathophysiology of coronary artery disease (CAD). Several types of sterile inflammation are mediated through the nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome. Colchicine has recently been shown to effectively block NLRP3 inflammasome assembly in addition to several other actions on inflammatory cells. Recent evidence also points to favorable effects of colchicine in patients with CAD, including lower levels of inflammatory markers, coronary plaque stabilization, and more favorable cardiac recovery after injury. This review focuses on the role of colchicine in the process of atherosclerosis and discusses its potential as a therapeutic option for the prevention and treatment of CAD.
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Citations
Citations to this article as recorded by
- Targeting the NLRP3 inflammasome with natural products for ischemia–reperfusion injury across organs: mechanisms, structure–activity relationships, and delivery innovations
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Inflammopharmacology.2025; 33(11): 6589. CrossRef - Colchicine as an Anti-Inflammatory Agent Improving Cancer Prognosis: A Therapeutic Repurposing Perspective
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